ABSTRACT
Objective To investigate the risks of pre-pregnancy overweight,excessive gestational weight gain on macrosomia.Methods We conducted one hospital-based cohort study,focusing on pregnant women from January 2015.All pregnant women attending to this hospital for maternal check-ups,were included in our cohort and followed to the time of delivery.Data related to general demographic characteristics,pregnancy and health status of those pregnant women,was collected and maternal pre-pregnant BMI and maternal weight gain were calculated.Logistic regression was used to explore the risk difference of pre-pregnancy BMI,excessive gestational weight gain on macrosomia.Results The overall incidence of macrosomia in our cohort appeared as 6.6％ (149/2 243).After adjusting the confounding factors including age and histories on pregnancy,prepregnancy overweight/obesity was associated with higher risks of macrosomia (OR=3.12,95％ CI:1.35-7.22,P=0.008;OR=2.99,95％CI:1.17-7.63,P=0.022) when comparing to those with normal pre-pregnancy weight.Cesarean delivery and sex of the offspring were associated with higher risk of macrosomia,while excessive gestational weight gain showed no significant difference (OR=1.41,95％CI:0.96-2.09,P=0.084).Our data showed that Macrosomia was statistically associated with gestational weight gain (P=0.002).After controlling parameters as age,history of pregnancy and related complications of the pregnant women,results from the logistic regression showed that women with gestational inadequate weight gain having reduced risks to deliver macrosomia,when compared to those pregnant women with adequate weight gain (OR=0.52,95％ CI:0.30-0.90,P=0.019).Conclusion Pre-pregnancy overweight and obesity were on higher risks to macrosomia.
ABSTRACT
Objective To investigate the risks of pre-pregnancy overweight,excessive gestational weight gain on macrosomia.Methods We conducted one hospital-based cohort study,focusing on pregnant women from January 2015.All pregnant women attending to this hospital for maternal check-ups,were included in our cohort and followed to the time of delivery.Data related to general demographic characteristics,pregnancy and health status of those pregnant women,was collected and maternal pre-pregnant BMI and maternal weight gain were calculated.Logistic regression was used to explore the risk difference of pre-pregnancy BMI,excessive gestational weight gain on macrosomia.Results The overall incidence of macrosomia in our cohort appeared as 6.6％ (149/2 243).After adjusting the confounding factors including age and histories on pregnancy,prepregnancy overweight/obesity was associated with higher risks of macrosomia (OR=3.12,95％ CI:1.35-7.22,P=0.008;OR=2.99,95％CI:1.17-7.63,P=0.022) when comparing to those with normal pre-pregnancy weight.Cesarean delivery and sex of the offspring were associated with higher risk of macrosomia,while excessive gestational weight gain showed no significant difference (OR=1.41,95％CI:0.96-2.09,P=0.084).Our data showed that Macrosomia was statistically associated with gestational weight gain (P=0.002).After controlling parameters as age,history of pregnancy and related complications of the pregnant women,results from the logistic regression showed that women with gestational inadequate weight gain having reduced risks to deliver macrosomia,when compared to those pregnant women with adequate weight gain (OR=0.52,95％ CI:0.30-0.90,P=0.019).Conclusion Pre-pregnancy overweight and obesity were on higher risks to macrosomia.
ABSTRACT
Objective To discuss the effect of α-lipoic acid combined with alprostadil in patients with diabetic peripheral neuropathy (DPN).Methods Eighty-two patients with DPN were divided into the control group(n=41) and research group(n=41) according to the random number table method.The patients of the control group were given alprostadil based on conventional therapy, while the research group were given alpha lipoic acid based on treatment of the control group, the course was two weeks.The bilateral median nerve and sural nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) were tested by electromyograph.Disease severity were evaluated by neuropathy symptoms questionnaire (TSS) and pain degree were tested by Visual analogue scales(VAS).The MNCV, SNCV, TSS and VAS of before and after treatment and the clinical effect of the two groups were compared.Results There were no statistically significant difference about MNCV and SNCV of the two groups before treatment (P＞0.05).After treatment, the MNCV and SNCV of nervus medianus and nervus peroneus communis of research group and control group were significantly higher than before treatment, and the differences of research group before and after treatment (MNCV of nervus medianus: (42.5 ± 3.6) m/s vs (47.8± 4.6) m/s, t =-5.752, P ＜ 0.05;SNCV of ervus medianus : (39.6 ±1.6) m/s vs (46.2±4.5) m/s,t =-5.882,P＜0.05;MNCV of nervus peroneus communis: (39.8±3.2) m/s vs (44.5±2.5) m/s,t=-4.263,P＜0.05;SNCV of nervus peroneus communis: (36.5±1.7) m/s vs (48.7± 2.6) m/s, t =-7.526, P ＜ 0.05), significantly obvious than the control group (MNCV of nervus medianus: (42.3 ±4.2) m/s vs (44.5±5.3) m/s,t =-4.627,P＜0.05;SNCV of nervus medianus: (39.8 ±2.4) m/s vs (42.4±2.5) m/s,t =-5.527,P＜0.05;MNCV of nervus peroneus communis: (40.3±1.6) m/s vs (42.2± 1.6) m/s, t =-4.181, P＜ 0.05;SNCV of nervus peroneus communis: (36.4± 2.3) m/s vs (41.2±3.5) m/s,t =-5.928,P＜0.05).Before the treatment,the TSS and VAS of the control group were (11.4±2.5) sore and (5.3±1.6) sore,of the research group were (11.6±1.6) sore and (5.2±1.8) sore,and there was no significant difference between the two groups (P＞0.05).After treatment, the TSS and VAS of the control group were (6.4± 1.3) sore and (3.6± 1.3) sore, of the research group were (4.2± 3.3) sore and (1.7 ±0.9) sore, and compared to before treatment, there was significant difference (P＜0.05), and the research group was significantly lower than the control group, the difference between the two groups was statistically significant (P＜ 0.05).The total effective rate of research group was obviously higher than that of control group, the differences were statistically significant (95.1％ (39/41) vs 65.9％ (27/41), x2 =5.363, P =0.031) .Conclusion The effect of α-lipoic acid combined with alprostadil in patients with diabetic peripheral neuropathy is obviously better than that of using alprostadil only,it is worth popularization and application.
ABSTRACT
Objective To investigate the effect of vascular endothelial growth factor (VEGF) on the leukocyle function in a rat denervated infect flap model and to investigate the action mechanison of VEGF in the flap anti-infection .Methods An island pedicle flap measured 2 cm × 2 cm was raised on the right abdomen of sixty wister rats ,which were divided into three groups .All flaps re-ceived intradermal inoculation of 107 Staphylococcus aureus ,and the animals were observed for 96 h .The indexes of the leukocyte count ,leukocyte vitality ,hemiluminescence of neutrophils ,tissue bacterial count ,naked eyes observation of falptissue and the light microscope observation were detected .Results The leukocyte count in the exudation at postoperative 96 h had no statistical differ-ences among 3 groups(P>0 .05);while in the indexes detection of the leukocyte vitality ,chemiluminescence of neutrophils ,tissue bacterial count ,etc .,the comparison between the chronic denervated group and the control group showed very significantly differ-ences(P<0 .01);the differences between the VEGF treatment group and the chronic denervated group was very significant (P<0 .01) .The falp pathological change in the control group and the VEGF treatment groups was slight .Conclusion The soft issue af-ter losing the innervation decreases the leukocyte function .VEGF might improve the flap micro circulation and play an important role in improving the leukocyte function .